Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.

@article{Jedrychowski2015DetectionAQ,
  title={Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry.},
  author={Mark P. Jedrychowski and Christiane D. Wrann and Joao A. Paulo and Kaitlyn K. Gerber and John Szpyt and Matthew M. Robinson and K. Sreekumaran Nair and Steven P Gygi and Bruce M. Spiegelman},
  journal={Cell metabolism},
  year={2015},
  volume={22 4},
  pages={
          734-740
        }
}
Exercise provides many health benefits, including improved metabolism, cardiovascular health, and cognition. We have shown previously that FNDC5, a type I transmembrane protein, and its circulating form, irisin, convey some of these benefits in mice. However, recent reports questioned the existence of circulating human irisin both because human FNDC5 has a non-canonical ATA translation start and because of claims that many human irisin antibodies used in commercial ELISA kits lack required… CONTINUE READING

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