Detection Times of Drugs of Abuse in Blood, Urine, and Oral Fluid

@article{Verstraete2004DetectionTO,
  title={Detection Times of Drugs of Abuse in Blood, Urine, and Oral Fluid},
  author={Alain G. Verstraete},
  journal={Therapeutic Drug Monitoring},
  year={2004},
  volume={26},
  pages={200-205}
}
  • A. Verstraete
  • Published 1 April 2004
  • Medicine
  • Therapeutic Drug Monitoring
Data on the detection times of drugs of abuse are based on studies of controlled administration to volunteers or on the analysis of biologic samples of subjects who are forced to stop their (often chronic) use of drugs of abuse, eg, because of imprisonment or detoxification. [...] Key Result In general, the detection time is longest in hair, followed by urine, sweat, oral fluid, and blood. In blood or plasma, most drugs of abuse can be detected at the low nanogram per milliliter level for 1 or 2 days.Expand
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Among all drug analytical methods the cheapest and easiest test to screening opioids and other abuse drugs in urine and blood samples is strip test for rapid diagnosis and TLC (thin-layer chromatography) is appropriate confirmation method to drug abuse distinguishing.
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TLDR
A sensitive multi-component method for quantitative determination of 50 drug compounds from oral fluid samples collected with the StatSure SalivaSampler™ device was developed, and at the moment the developed method is the most comprehensive validated analysis method for Oral fluid samples.
Bioanalytical procedures and recent developments in the determination of opiates/opioids in human biological samples
TLDR
Recently published articles that describe procedures for the detection of opiates in the most commonly used human biological matrices, blood and urine, and also in unconventional ones, e.g. oral fluid, hair, and meconium are reviewed.
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Investigation times for detection of drugs in urine vary depending on dose and route of administration, metabolism and characteristics of the screening and confirmation assays, particularly for heroin and designer amphetamines.
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