Detection Times of Drugs of Abuse in Blood, Urine, and Oral Fluid

@article{Verstraete2004DetectionTO,
  title={Detection Times of Drugs of Abuse in Blood, Urine, and Oral Fluid},
  author={Alain G. Verstraete},
  journal={Therapeutic Drug Monitoring},
  year={2004},
  volume={26},
  pages={200-205}
}
  • A. Verstraete
  • Published 1 April 2004
  • Medicine
  • Therapeutic Drug Monitoring
Data on the detection times of drugs of abuse are based on studies of controlled administration to volunteers or on the analysis of biologic samples of subjects who are forced to stop their (often chronic) use of drugs of abuse, eg, because of imprisonment or detoxification. [] Key Result In general, the detection time is longest in hair, followed by urine, sweat, oral fluid, and blood. In blood or plasma, most drugs of abuse can be detected at the low nanogram per milliliter level for 1 or 2 days.
Very long Detection Times after High and repeated intake of Heroin and Methadone, measured in Oral Fluid
TLDR
Oral fluid is likely to become a good method for detection of drug abuse in the future and Elimination curves for methadone in oral fluid were found for two subjects, and the detection times were 5 and 8 days.
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TLDR
Combined use of questionnaires/interviews and drug testing detects more drug use than when using only one of those methods and is therefore expected to give more accurate data.
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TLDR
Concerns are discussed, such as the variability in the volume of sample collected and its implications in terms of quantitative measurements, and the drug recoveries of the many different specimen collection systems on the market.
Comparison of Oral Fluid and Urine for Detection of Cocaine Abuse Using Liquid Chromatography with Tandem Mass Spectrometry.
TLDR
It is demonstrated that OF detects more COC abuse in an AMP setting when UR BZE cutoffs ≥ 50 µg/L are utilized, and that UR creatinine concentrations are significantly lower in specimens positive for COC and/or BZE in OF and negative for BZe in UR.
Screening for drugs of abuse: which matrix, oral fluid or urine?
  • K. Allen
  • Medicine, Biology
    Annals of clinical biochemistry
  • 2011
TLDR
Advances in analytical techniques, particularly chromatography linked to tandem mass spectrometry, are helping to promote oral fluid analysis, but the lack of concordance studies examining both urine and oral fluid drug levels and kinetics in the clinical setting is of some concern.
Interpretation of Oral Fluid Tests for Drugs of Abuse
TLDR
This review delineates many of the chemical and metabolic processes involved in the disposition of drugs and metabolites in oral fluid that are important to the appropriate interpretation of oral fluid tests.
Distinguishing of Abuse Drugs in Urine and Blood Samples of Abusers in Iran
TLDR
Among all drug analytical methods the cheapest and easiest test to screening opioids and other abuse drugs in urine and blood samples is strip test for rapid diagnosis and TLC (thin-layer chromatography) is appropriate confirmation method to drug abuse distinguishing.
Bioanalytical procedures and recent developments in the determination of opiates/opioids in human biological samples
TLDR
Recently published articles that describe procedures for the detection of opiates in the most commonly used human biological matrices, blood and urine, and also in unconventional ones, e.g. oral fluid, hair, and meconium are reviewed.
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TLDR
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TLDR
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