Detection, identification and in vivo treatment responsiveness of bone morphogenetic protein (BMP)-activated cell populations in the synovium of patients with rheumatoid arthritis.

@article{Verschueren2009DetectionIA,
  title={Detection, identification and in vivo treatment responsiveness of bone morphogenetic protein (BMP)-activated cell populations in the synovium of patients with rheumatoid arthritis.},
  author={Patrick C P M Verschueren and Rik J. U. Lories and Melina Daans and Ivan Th{\'e}ate and Patrick Durez and Ren{\'e} Westhovens and Frank P. Luyten},
  journal={Annals of the rheumatic diseases},
  year={2009},
  volume={68 1},
  pages={117-23}
}
OBJECTIVE To characterise the bone morphogenetic protein (BMP) target cells positive for phosphorylated (P)-SMAD1/5, in rheumatoid arthritis (RA) synovium. METHODS Synovial biopsies were obtained by needle arthroscopy. Anti-P-SMAD1/5 antibodies were used for Western blot (WB) on protein extracts from RA and normal synovium and for immunostaining of synovial biopsy sections. Positive cells were further identified by double staining for CD3, CD20, CD68, CD138, CD90, alpha smooth muscle actin… CONTINUE READING
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