Detecting the undetected: estimating the total number of loci underlying a quantitative trait.

@article{Otto2000DetectingTU,
  title={Detecting the undetected: estimating the total number of loci underlying a quantitative trait.},
  author={Sarah P. Otto and Corbin D. Jones},
  journal={Genetics},
  year={2000},
  volume={156 4},
  pages={2093-107}
}
Recent studies have begun to reveal the genes underlying quantitative trait differences between closely related populations. Not all quantitative trait loci (QTL) are, however, equally likely to be detected. QTL studies involve a limited number of crosses, individuals, and genetic markers and, as a result, often have little power to detect genetic factors of small to moderate effects. In this article, we develop an estimator for the total number of fixed genetic differences between two parental… CONTINUE READING