Detecting selective sweeps: a new approach based on hidden markov models.

Abstract

Detecting and localizing selective sweeps on the basis of SNP data has recently received considerable attention. Here we introduce the use of hidden Markov models (HMMs) for the detection of selective sweeps in DNA sequences. Like previously published methods, our HMMs use the site frequency spectrum, and the spatial pattern of diversity along the sequence… (More)
DOI: 10.1534/genetics.108.100032

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