Detecting recent positive selection in the human genome from haplotype structure

@article{Sabeti2002DetectingRP,
  title={Detecting recent positive selection in the human genome from haplotype structure},
  author={Pardis C Sabeti and D. Reich and J. Higgins and Haninah Z. P. Levine and D. Richter and S. Schaffner and S. Gabriel and J. Platko and N. Patterson and G. McDonald and H. Ackerman and S. J. Campbell and D. Altshuler and Richard Cooper and D. Kwiatkowski and R. Ward and E. Lander},
  journal={Nature},
  year={2002},
  volume={419},
  pages={832-837}
}
The ability to detect recent natural selection in the human population would have profound implications for the study of human history and for medicine. Here, we introduce a framework for detecting the genetic imprint of recent positive selection by analysing long-range haplotypes in human populations. We first identify haplotypes at a locus of interest (core haplotypes). We then assess the age of each core haplotype by the decay of its association to alleles at various distances from the locus… Expand
A method for detecting recent selection in the human genome from allele age estimates.
Screening for recently selected alleles by analysis of human haplotype similarity.
Genome-wide comparison of African-ancestry populations from CARe and other cohorts reveals signals of natural selection.
Genomic landscape of positive natural selection in Northern European populations
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