Detecting natural selection in RNA virus populations using sequence summary statistics.

@article{Bhatt2010DetectingNS,
  title={Detecting natural selection in RNA virus populations using sequence summary statistics.},
  author={Samir Bhatt and Aris Katzourakis and Oliver G. Pybus},
  journal={Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases},
  year={2010},
  volume={10 3},
  pages={
          421-30
        }
}
At present, most analyses that aim to detect the action of natural selection upon viral gene sequences use phylogenetic estimates of the ratio of silent to replacement mutations. Such methods, however, are impractical to compute on large data sets comprising hundreds of complete viral genomes, which are becoming increasingly common due to advances in genome sequencing technology. Here we investigate the statistical performance of computationally efficient tests that are based on sequence… CONTINUE READING
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