This research evaluates the Venoscope for its ability to detect infiltrations when present (sensitivity) and to detect the absence of infiltrations when not present (specificity), and compares these findings with those obtained via ultrasonography. Health adult volunteers were randomly assigned to receive or not receive an intentionally made 5-ml normal-saline infiltration. The Venoscope had a sensitivity of .92-.93 and a specificity of .89-1.0. Ultrasound had a sensitivity of .92-.93 and a specificity of .22-.25. The Venoscope, which is simple and easy to use, is a valid indicator of the presence and absence of i.v. infiltrations.