Detecting hierarchical structure in molecular characteristics of disease using transitive approximations of directed graphs

Abstract

MOTIVATION Molecular diagnostics aims at classifying diseases into clinically relevant sub-entities based on molecular characteristics. Typically, the entities are split into subgroups, which might contain several variants yielding a hierarchical model of the disease. Recent years have introduced a plethora of new molecular screening technologies to… (More)
DOI: 10.1093/bioinformatics/btn056

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