Detecting genotyping error using measures of degree of Hardy-Weinberg disequilibrium.

Abstract

Tests for Hardy-Weinberg equilibrium (HWE) have been used to detect genotyping error, but those tests have low power unless the sample size is very large. We assessed the performance of measures of departure from HWE as an alternative way of screening for genotyping error. Three measures of the degree of disequilibrium (alpha, ,D, and F) were tested for… (More)
DOI: 10.2202/1544-6115.1463

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Cite this paper

@article{Attia2010DetectingGE, title={Detecting genotyping error using measures of degree of Hardy-Weinberg disequilibrium.}, author={John R Attia and Ammarin Thakkinstian and Patrick Mcelduff and Elizabeth Milne and Somer Dawson and R. J. Scott and Nicholas de Klerk and Bruce Armstrong and John R. Thompson}, journal={Statistical applications in genetics and molecular biology}, year={2010}, volume={9}, pages={Article 5} }