Detecting gene clusters under evolutionary constraint in a large number of genomes

  title={Detecting gene clusters under evolutionary constraint in a large number of genomes},
  author={Xu Ling and Xin He and Dong Xin},
  volume={25 5},
MOTIVATION Spatial clusters of genes conserved across multiple genomes provide important clues to gene functions and evolution of genome organization. Existing methods of identifying these clusters often made restrictive assumptions, such as exact conservation of gene order, and relied on heuristic algorithms. RESULTS We developed a very efficient algorithm based on a 'gene teams' model that allows genes in the clusters to appear in different orders. This allows us to detect conserved gene… CONTINUE READING
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