Detecting gene clusters under evolutionary constraint in a large number of genomes

@article{Ling2009DetectingGC,
  title={Detecting gene clusters under evolutionary constraint in a large number of genomes},
  author={Xu Ling and Xin He and Dong Xin},
  journal={Bioinformatics},
  year={2009},
  volume={25 5},
  pages={571-7}
}
MOTIVATION Spatial clusters of genes conserved across multiple genomes provide important clues to gene functions and evolution of genome organization. Existing methods of identifying these clusters often made restrictive assumptions, such as exact conservation of gene order, and relied on heuristic algorithms. RESULTS We developed a very efficient algorithm based on a 'gene teams' model that allows genes in the clusters to appear in different orders. This allows us to detect conserved gene… CONTINUE READING
Highly Cited
This paper has 50 citations. REVIEW CITATIONS

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Finding approximate gene clusters with Gecko 3

Nucleic acids research • 2016
View 9 Excerpts
Highly Influenced

A New Efficient Algorithm for the Gene-Team Problem on General Sequences

IEEE/ACM Transactions on Computational Biology and Bioinformatics • 2012
View 7 Excerpts
Highly Influenced

Statistics for approximate gene clusters

View 4 Excerpts
Highly Influenced

51 Citations

051015'11'13'15'17'19
Citations per Year
Semantic Scholar estimates that this publication has 51 citations based on the available data.

See our FAQ for additional information.

References

Publications referenced by this paper.
Showing 1-10 of 42 references

Gene teams with relaxed proximity constraint

2005 IEEE Computational Systems Bioinformatics Conference (CSB'05) • 2005
View 16 Excerpts
Highly Influenced

The Algorithmic of Gene Teams

View 5 Excerpts
Highly Influenced

Gene context conservation of a higher order than operons.

Trends in biochemical sciences • 2000
View 7 Excerpts
Highly Influenced

The use of gene clusters to infer functional coupling.

Proceedings of the National Academy of Sciences of the United States of America • 1999
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…