Detecting functional interactions in a gene and signaling network by time-resolved somatic complementation analysis.

@article{Marwan2003DetectingFI,
  title={Detecting functional interactions in a gene and signaling network by time-resolved somatic complementation analysis.},
  author={Wolfgang Marwan},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  year={2003},
  volume={25 10},
  pages={950-60}
}
  • Wolfgang Marwan
  • Published 2003 in
    BioEssays : news and reviews in molecular…
Somatic complementation by fusion of two mutant cells and mixing of their cytoplasms occurs when the genetic defect of one fusion partner is cured by the functional gene product provided by the other. We have found that complementation of mutational defects in the network mediating stimulus-induced commitment and sporulation of Physarum polycephalum may… CONTINUE READING