Detecting drug targets with minimum side effects in metabolic networks.

@article{Li2009DetectingDT,
  title={Detecting drug targets with minimum side effects in metabolic networks.},
  author={Zhaohua Li and R Wang and Xu-Sheng Zhang and Liqun Chen},
  journal={IET systems biology},
  year={2009},
  volume={3 6},
  pages={523-33}
}
High-throughput techniques produce massive data on a genome-wide scale which facilitate pharmaceutical research. Drug target discovery is a crucial step in the drug discovery process and also plays a vital role in therapeutics. In this study, the problem of detecting drug targets was addressed, which finds a set of enzymes whose inhibition stops the production of a given set of target compounds and meanwhile minimally eliminates non-target compounds in the context of metabolic networks. The… CONTINUE READING

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