Detecting dose-response using contrasts: asymptotic power and sample size determination for binomial data.

@article{Bretz2002DetectingDU,
  title={Detecting dose-response using contrasts: asymptotic power and sample size determination for binomial data.},
  author={Frank Bretz and L. A. Hothorn},
  journal={Statistics in medicine},
  year={2002},
  volume={21 22},
  pages={3325-35}
}
Recently, Stewart and Ruberg proposed the use of contrast tests for detecting dose-response relationships. They considered in particular bivariate contrasts for healing rates and gave several possibilities of defining adequate sets of coefficients. This paper extends their work in several directions. First, asymptotic power expressions for both single and… CONTINUE READING