Detecting distant homologs using phylogenetic tree-based HMMs.

@article{Qian2003DetectingDH,
  title={Detecting distant homologs using phylogenetic tree-based HMMs.},
  author={Bin Qian and Richard A. Goldstein},
  journal={Proteins},
  year={2003},
  volume={52 3},
  pages={446-53}
}
It is often desired to identify further homologs of a family of biological sequences from the ever-growing sequence databases. Profile hidden Markov models excel at capturing the common statistical features of a group of biological sequences. With these common features, we can search the biological database and find new homologous sequences. Most general profile hidden Markov model methods, however, treat the evolutionary relationships between the sequences in a homologous group in an ad-hoc… CONTINUE READING
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