Detecting deamidation products in proteins by electron capture dissociation.

  title={Detecting deamidation products in proteins by electron capture dissociation.},
  author={Jason J Cournoyer and Cheng Bill Lin and Peter B. O'Connor},
  journal={Analytical chemistry},
  volume={78 4},
A nonenzymatic posttranslational modification of proteins and peptides is the spontaneous deamidation of asparaginyl residues via a succinimide intermediate to form a varying mixture of aspartyl and isoaspartyl residues. The isoaspartyl residue is generally difficult to detect particularly using mass spectrometry because isoaspartic acid is isomeric with aspartic acid so that there is no mass difference. However, electron capture dissociation has demonstrated the ability to differentiate the… CONTINUE READING
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