Detecting and understanding combinatorial mutation patterns responsible for HIV drug resistance.

@article{Zhang2010DetectingAU,
  title={Detecting and understanding combinatorial mutation patterns responsible for HIV drug resistance.},
  author={Jing Zhang and Tingjun Hou and Wei Wang and Jun S. Liu},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2010},
  volume={107 4},
  pages={1321-6}
}
We propose a systematic approach for a better understanding of how HIV viruses employ various combinations of mutations to resist drug treatments, which is critical to developing new drugs and optimizing the use of existing drugs. By probabilistically modeling mutations in the HIV-1 protease or reverse transcriptase (RT) isolated from drug-treated patients, we present a statistical procedure that first detects mutation combinations associated with drug resistance and then infers detailed… CONTINUE READING
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