Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry.

@article{Ma2006DetectingAC,
  title={Detecting and characterizing reactive metabolites by liquid chromatography/tandem mass spectrometry.},
  author={Shuguang Ma and Ramakrishnan Subramanian},
  journal={Journal of mass spectrometry : JMS},
  year={2006},
  volume={41 9},
  pages={
          1121-39
        }
}
Metabolic activation of a drug leading to reactive metabolite(s) that can covalently modify proteins is considered an initial step that may lead to drug-induced organ toxicities. Characterization of reactive metabolites is critical to designing new drug candidates with an improved toxicological profile. High performance liquid chromatography (HPLC) coupled with mass spectrometry (MS) predominates over all analytical tools used for screening and characterization of reactive metabolites. In this… CONTINUE READING
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