Detecting adverse drug reactions following long-term exposure in longitudinal observational data: The exposure-adjusted self-controlled case series.

@article{Schuemie2016DetectingAD,
  title={Detecting adverse drug reactions following long-term exposure in longitudinal observational data: The exposure-adjusted self-controlled case series.},
  author={Martijn J. Schuemie and Gianluca Trifir{\`o} and Preciosa M. Coloma and Patrick B. Ryan and David Madigan},
  journal={Statistical methods in medical research},
  year={2016},
  volume={25 6},
  pages={2577-2592}
}
Most approaches used in postmarketing drug safety monitoring, including spontaneous reporting and statistical risk identification using electronic health care records, are primarily suited to pick up only acute adverse drug effects. With the availability of increasingly larger electronic health record and administrative claims databases comes the… CONTINUE READING