Detecting Arbitrary DNA Mutations Using Graphene Oxide and Ethidium Bromide.


We propose a simple and fast method for detecting arbitrary DNA mutations. Single-stranded DNA probes labeled with fluorescein amidite (FAM-ssDNA), ethidium bromide (EB), and graphene oxide (GO) are employed in the sensing system. The detection is achieved in two steps. In the first step, the sensing system contains FAM-ssDNA probes and EB molecules. It… (More)
DOI: 10.1021/acs.analchem.5b03369