Detectable reporter gene expression following transduction of adenovirus and adeno-associated virus serotype 2 vectors within full-thickness osteoarthritic and unaffected canine cartilage in vitro and unaffected guinea pig cartilage in vivo.

Abstract

This study quantified and compared the transduction efficiencies of adenoviral (Ad), Arg-Gly-Asp (RGD)-modified Ad, adeno-associated viral serotype 2 (AAV2), and self-complementary AAV2 (scAAV2) vectors within full-thickness osteoarthritic (OA) and unaffected canine cartilage explants in vitro. Intraarticular administration of Ad and scAAV2 vectors was… (More)
DOI: 10.1002/jor.20975

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@article{Santangelo2010DetectableRG, title={Detectable reporter gene expression following transduction of adenovirus and adeno-associated virus serotype 2 vectors within full-thickness osteoarthritic and unaffected canine cartilage in vitro and unaffected guinea pig cartilage in vivo.}, author={Kelly S. Santangelo and Sarah A Baker and Gerard Jerry Nuovo and Jonathan Dyce and Jeffrey Bartlett and Alicia L. Bertone}, journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society}, year={2010}, volume={28 2}, pages={149-55} }