Detectable colonic nitrite levels in inflammatory bowel disease--mucosal or bacterial malfunction?

@article{Roediger1986DetectableCN,
  title={Detectable colonic nitrite levels in inflammatory bowel disease--mucosal or bacterial malfunction?},
  author={William E Roediger and M. J. Lawson and Scott Nance and B. C. Radcliffe},
  journal={Digestion},
  year={1986},
  volume={35 4},
  pages={199-204}
}
In the healthy colon, sodium nitrite stimulates mucosal metabolism of short-chain fatty acids and absorption of ions, both functions that are impaired in the mucosa of patients with ulcerative colitis (UC). To assess the role of nitrite in colonic inflammatory disease, sodium nitrite was measured in rectal dialysate of 49 subjects (18 controls, 23 UC and 8 other colitis). None of the control or quiescent UC patients had measurable levels of nitrite while 78% of patients with acute UC and 38% of… CONTINUE READING

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