Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.

@article{Jiang2006DetailsOT,
  title={Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis.},
  author={Zhengfan Jiang and P. Georgel and C. Li and J. Choe and K. Crozat and S. Rutschmann and Xin Du and T. Bigby and S. Mudd and S. Sovath and I. Wilson and A. Olson and B. Beutler},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 29},
  pages={
          10961-6
        }
}
The immunovariant N-ethyl-N-nitrosourea-induced mutations Pococurante (Poc) and Lackadaisical were found to alter MyD88, creating striking receptor-selective effects. Poc, in particular, prevented sensing of all MyD88-dependent Toll-like receptor (TLR) ligands except diacyl lipopeptides. Furthermore, Poc-site and classical BB loop mutations caused equivalent phenotypes when engrafted into any TLR/IL-1 receptor/resistance (TIR) domain. These observations, complemented by data from docking… Expand
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