Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities.

@article{Xu2016DetailsIT,
  title={Details in the catalytic mechanism of mammalian thioredoxin reductase 1 revealed using point mutations and juglone-coupled enzyme activities.},
  author={Jianqiang Xu and Qing Cheng and Elias S. J. Arn{\'e}r},
  journal={Free radical biology & medicine},
  year={2016},
  volume={94},
  pages={110-20}
}
The mammalian selenoprotein thioredoxin reductase 1 (TrxR1) is a key enzyme in redox regulation, antioxidant defense, and cellular growth. TrxR1 can catalyze efficient reduction of juglone (5-hydroxy-1,4-naphthoquinone; walnut toxin) in a reaction which, in contrast to reduction of most other substrates of TrxR1, is not dependent upon an intact… CONTINUE READING