Detailed structural and quantitative analysis reveals the spatial organization of the cell walls of in vivo grown Mycobacterium leprae and in vitro grown Mycobacterium tuberculosis.

@article{Bhamidi2011DetailedSA,
  title={Detailed structural and quantitative analysis reveals the spatial organization of the cell walls of in vivo grown Mycobacterium leprae and in vitro grown Mycobacterium tuberculosis.},
  author={Suresh Bhamidi and Michael S. Scherman and Victoria C. Jones and Dean C Crick and John T. Belisle and Patrick Joseph Brennan and Michael R. McNeil},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 26},
  pages={23168-77}
}
The cell wall of mycobacteria consists of an outer membrane, analogous to that of gram-negative bacteria, attached to the peptidoglycan (PG) via a connecting polysaccharide arabinogalactan (AG). Although the primary structure of these components is fairly well deciphered, issues such as the coverage of the PG layer by covalently attached mycolates in the outer membrane and the spatial details of the mycolic acid attachment to the arabinan have remained unknown. It is also not understood how… CONTINUE READING
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