Detailed simulation of cancer exome sequencing data reveals differences and common limitations of variant callers

@inproceedings{Hofmann2016DetailedSO,
  title={Detailed simulation of cancer exome sequencing data reveals differences and common limitations of variant callers},
  author={Ariane L. Hofmann and Jonas Behr and Jochen Singer and Jack Kuipers and Christian Beisel and Peter Schraml and Holger Moch and Niko Beerenwinkel},
  booktitle={BMC Bioinformatics},
  year={2016}
}
Next-generation sequencing of matched tumor and normal biopsy pairs has become a technology of paramount importance for precision cancer treatment. Sequencing costs have dropped tremendously, allowing the sequencing of the whole exome of tumors for just a fraction of the total treatment costs. However, clinicians and scientists cannot take full advantage of… CONTINUE READING