Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue-Behavioural, pharmacokinetic and metabolic studies in the Wistar rat.

@article{Horsley2016DetailedPE,
  title={Detailed pharmacological evaluation of methoxetamine (MXE), a novel psychoactive ketamine analogue-Behavioural, pharmacokinetic and metabolic studies in the Wistar rat.},
  author={Rachel R. Horsley and Eva Lhotkov{\'a} and Katerina H{\'a}jkov{\'a} and Bronislav Jur{\'a}sek and Martin Kuchař and Tomas Palenicek},
  journal={Brain research bulletin},
  year={2016},
  volume={126 Pt 1},
  pages={102-110}
}
Methoxetamine (MXE) is a novel psychoactive compound (NPS) that emerged in 2010 as a substitute for the dissociative anaesthetic ketamine. MXE has a reputation of carrying a lower risk of harm than ketamine, however a number of deaths have been reported. Currently very little is known about the psychopharmacological effects of this compound or its toxicity; therefore we tested, in Wistar rats, the effects of MXE in a series of behavioural tasks, measured its pharmacokinetics and urinary… CONTINUE READING
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