Detailed mutational analysis of Vga(A) interdomain linker: implication for antibiotic resistance specificity and mechanism.


Detailed mutational analysis examines the roles of individual residues of the Vga(A) linker in determining the antibiotic resistance phenotype. It defines a narrowed region of residues 212 to 220 whose composition determines the resistance specificity to lincosamides, pleuromutilins, and/or streptogramins A. From the analogy with the recently described… (More)
DOI: 10.1128/AAC.04468-14

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