Detailed low-dose study of 1,1-bis(p-chlorophenyl)-2,2,2- trichloroethane carcinogenesis suggests the possibility of a hormetic effect.

@article{Sukata2002DetailedLS,
  title={Detailed low-dose study of 1,1-bis(p-chlorophenyl)-2,2,2- trichloroethane carcinogenesis suggests the possibility of a hormetic effect.},
  author={Tokuo Sukata and Satoshi Uwagawa and Keisuke Ozaki and Motome Ogawa and Takayuki Nishikawa and Syuji Iwai and Anna Kinoshita and Hideki Wanibuchi and Susumu Imaoka and Yoshihiko Funae and Yasuyoshi Okuno and Shoji Fukushima},
  journal={International journal of cancer},
  year={2002},
  volume={99 1},
  pages={112-8}
}
To obtain information on the effects of nongenotoxic carcinogens at low doses for human cancer risk assessment, the carcinogenic potential of the organochlorine insecticide, 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT), in the liver was assessed in F344 rats. In experiment 1, 240 male animals, 21 days old, were administered 0, 0.5, 1.0, 2.0, 5.0, 20, 100 and 500 ppm DDT in the diet for 16 weeks. Experiment 2 was conducted to elucidate the carcinogenic potential of DDT at lower levels… CONTINUE READING

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