Detailed kinetic analysis of the interaction between the FOXO4-DNA-binding domain and DNA.

@article{Vcha2013DetailedKA,
  title={Detailed kinetic analysis of the interaction between the FOXO4-DNA-binding domain and DNA.},
  author={Petr V{\'a}cha and Iva Zuskov{\'a} and Ladislav Bumba and P. T. D. Herman and Jaroslav Ve{\vc}eř and Veronika Ob{\vs}ilov{\'a} and Tom{\'a}{\vs} Ob{\vs}il},
  journal={Biophysical chemistry},
  year={2013},
  volume={184},
  pages={68-78}
}
The FOXO forkhead transcription factors are potent transcriptional activators involved in a wide range of key biological processes. In this work, the real-time kinetics of the interaction between the FOXO4-DNA binding domain (FOXO4-DBD) and the DNA was studied by using surface plasmon resonance (SPR). SPR analysis revealed that the interaction between FOXO4… CONTINUE READING