Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease.

@article{Bandmann2000DetailedGD,
  title={Detailed genotyping demonstrates association between the slow acetylator genotype for N-acetyltransferase 2 (NAT2) and familial Parkinson's disease.},
  author={Oliver Bandmann and Jenny R Vaughan and Peter Holmans and C. David Marsden and Nicholas Wood},
  journal={Movement disorders : official journal of the Movement Disorder Society},
  year={2000},
  volume={15 1},
  pages={30-5}
}
In a preliminary report we demonstrated an association between the slow acetylator genotype of N-acetyltransferase 2 (NAT2) and familial cases of Parkinson's disease (FPD). Using a considerably more precise NAT2 typing method, which detects all mutant NAT2 alleles with a frequency of >1% in the white population, we have now retyped all the original patients and control subjects to investigate the reliability of our initial findings. The slow acetylator genotype remained considerably more common… CONTINUE READING

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