Detailed genetic characterization of the interleukin-23 receptor in psoriasis

  title={Detailed genetic characterization of the interleukin-23 receptor in psoriasis},
  author={Ver{\'o}nica Edith Garc{\'i}a and Mira Chang and R Brandon and Y Li and Norisada Matsunami and Kristina P. Callis-Duffin and Daniel Civello and Charles M. Rowland and Ngoc Nam Bui and Joseph J. Catanese and Gerald G. Krueger and Mark F. Leppert and Ann B. Begovich and Steven J Schrodi},
  journal={Genes and Immunity},
Using a multi-tiered, case–control association design, scanning 25 215 gene-centric SNPs, we previously identified two psoriasis susceptibility genes: IL12B and IL23R. These results have recently been confirmed. To better characterize the IL23R psoriasis-association, we used a fine mapping strategy to identify 59 additional IL23R-linked SNPs, which were genotyped in our three independent, white North American sample sets (>2800 individuals in toto). A sliding window of haplotype association… CONTINUE READING

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