Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease

  title={Detailed comparison of amyloid PET and CSF biomarkers for identifying early Alzheimer disease},
  author={Mattias Olsson and Oskar Hansson and Lennart Minthon and H. Toresson and Katarina N{\"a}gga and Sebastian Palmqvist and Erik Stomrud and Per Johansson and Christer Nilsson and Maria Nilsson and Niklas Mattsson and Daniel Lindqvist and Susanna Vestberg and Shorena Janelidze and Henrik Zetterberg and K Blennow and Ulf Andr{\'e}asson and Danielle van Westen and Jimmy L{\"a}tt and Peter Mannfolk and Markus Nilsson and Olof T Strandberg and Pia C. Sundgren and Freddy St{\aa}hlberg and Olof Lindberg and Eric Westman and Lars-Olof Wahlund and Per Wollmer and Ruben Smith and Tomas Olsson and Michael Weiner and William Z. Potter and Robert C Green and Tom Montine and Paul S. Aisen and Ronald G. Thomas and M. Donohue and Sarah E. Walter and Clifford R. Jack and A. G. Dale and Matthew Bernstein and Joel P. Felmlee and Nick Fox and Paul Thompson and Norbert Schuff and Gene E. Alexander and William J. Jagust and D. E. Bandy and Robert A. Koeppe and Norm Foster and Eric M. Reiman and Kewei Chen and Chet A. Mathis and John C. Morris and Nigel J. Cairns and Lisa Taylor-Reinwald and J. Q. Trojanowki and Les M. Shaw and Virginia M. Y. Lee and Magdalena Korecka and Arthur W. Toga and Karen Crawford and Scott Neu and Laurel Beckett and Danielle Harvey and Anthony Gamst and John Kornak and Tatiana Foroud and Steven G. Potkin and Li Shen and Zaven Kachaturian and Richard Frank and Peter J. Snyder and Susan Molchan and Jeffrey Kaye and Sara Dolen and Joseph T. Quinn and L. S. Schneider and Sonia Pawluczyk and Bryan M. Spann and James Brewer and Helen Vanderswag and Judith L. Heidebrink and Joanne L. Lord and Ronald Petersen and Karen Johnson and Rachelle Doody and Javier Villanueva-Meyer and Munir Chowdhury and Yaakov Stern and Lawrence S. Honig and Karen L. Bell and Mark A. Mintun and Stacy Schneider and Daniel Marson and Randall G Griffith and David Clark and Hillel Z Grossman and Cheuk Tang and George Marzloff and Leyla deToledo-Morrell and Raj C. Shah and Ranjan Duara and Daniel J. Varon and Peggy Roberts CAN and Marilyn S. Albert and Nicholas Kozauer and M. Zerrate and Henry Rusinek and Mony J de Leon and Susan M De Santi and P. Murali Doraiswamy and Jeffrey R. Petrella and Marilyn Aiello and Steve Arnold and Jason H. T. Karlawish and David A. Wolk and Charles D. Smith and Curtis A. Given and Peter A. Hardy and Oscar L. Lopez and M. Oakley and Donna M. Simpson and M. Saleem Ismail and Connie Brand and Jennifer T Richard and Ruth A. Mulnard and Gaby Thai and Catherine Mc-Adams-Ortiz and Ramon Diaz-Arrastia and Kristen Martin-Cook and Michael Devous and Allan I. Levey and James J Lah and Janet S. Cellar and Jeffrey M. Burns and Heather S. Anderson and Mary M. Laubinger and Liana G. Apostolova and Daniel H. S. Silverman and P. H. Lu and Neill R. Graff-Radford and Francine C. Parfitt and Heather H Johnson and Martin R. Farlow and Scott Herring and Ann Marie Hake and Christopher H. van Dyck and Martha G Macavoy and Amanda L. Benincasa and Howard M. Chertkow and Howard Bergman and Chris Hosein and Sandra E. Black and Bojana Stefanovic and Curtis Caldwell and Ging-Yuek Robin Hsiung and Howard Feldman and Michele Assaly and Andrew Kertesz and John Rogers and Dick Trost and C Bernick and Donna Munic and Chuang-Kuo Wu and Nancy Johnson and M - Marsel Mesulam and Carl H. Sadowsky and Walter Martinez and Teresa Villena and Raymond Scott Turner and Kathleen Johnson and Brigid A. Reynolds and Reisa A. Sperling and Dorene M. Rentz and Keith A. Johnson and Allyson C. Rosen and Jared Tinklenberg and Wes Ashford and Marwan N. Sabbagh and Donald J. Connor and Sandra Jacobson and Ronald J. Killiany and Alexander Norbash and Anil Nair and Thomas O. Obisesan and Annapurni Jayam-Trouth and Paul Wang and Alan J. Lerner and Leon Hudson and Paula J Ogrocki and Charles DeCarli and Evan Fletcher and Owen T. Carmichael and Smita Kittur and Michael Borrie and T -Y Lee and Rob Bartha and Sterling C. Johnson and Sanjay Asthana and Cynthia M. Carlsson and Adrian Preda and Dana Nguyen and Pierre N. Tariot and Adam Fleisher and Stephanie Reeder and Vernice Bates and Horacio A Capote and Michelle M Rainka and Barry A. Hendin and Douglas W Scharre and Maria Kataki and Earl A. Zimmerman and Dzintra F Celmins and Alice E. Brown and Godfrey D. Pearlson and Karen Blank and Karen S. Anderson and Andrew J. Saykin and Robert B. Santulli and Jessica Englert and Jeff D. Williamson and Kaycee M Sink and F. J. Watkins and Brian R. Ott and Edward G. Stopa and Geoffrey Tremont and Stephen P. Salloway and Paul Malloy and Stephen Correia and Howard J. Rosen and Jacobo E. Mintzer and Crystal V Flynn Longmire and Kenneth M. Spicer},
OBJECTIVE To compare the diagnostic accuracy of CSF biomarkers and amyloid PET for diagnosing early-stage Alzheimer disease (AD). METHODS From the prospective, longitudinal BioFINDER study, we included 122 healthy elderly and 34 patients with mild cognitive impairment who developed AD dementia within 3 years (MCI-AD). β-Amyloid (Aβ) deposition in 9 brain regions was examined with [18F]-flutemetamol PET. CSF was analyzed with INNOTEST and EUROIMMUN ELISAs. The results were replicated in 146… CONTINUE READING
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Comparing PET imaging and CSF measurements of A b

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