Detailed behavioral analysis of water maze acquisition under APV or CNQX: contribution of sensorimotor disturbances to drug-induced acquisition deficits.

@article{Cain1996DetailedBA,
  title={Detailed behavioral analysis of water maze acquisition under APV or CNQX: contribution of sensorimotor disturbances to drug-induced acquisition deficits.},
  author={Donald Peter Cain and Deborah M. Saucier and Jeremy Hall and Eric L. Hargreaves and Francis Boon},
  journal={Behavioral neuroscience},
  year={1996},
  volume={110 1},
  pages={
          86-102
        }
}
N-methyl-D-aspartate (NMDA) receptor antagonists disrupt acquisition of the water maze and cause sensorimotor disturbances. In a detailed behavioral analysis in male rats, it was found that the NMDA antagonist DL-2-aminophosphonovaleric acid (APV) caused sensorimotor disturbances in behaviors required for maze performance and that these correlated with acquisition impairments in both hidden and visible platform versions of the maze. Behavioral disturbances included thigmotaxic swimming… CONTINUE READING

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