Detailed analysis of the CD8+ T-cell response following adenovirus vaccination.

@article{Yang2003DetailedAO,
  title={Detailed analysis of the CD8+ T-cell response following adenovirus vaccination.},
  author={Teng Chih Yang and Kelley Dayball and Yong Hong Wan and Jonathan L Bramson},
  journal={Journal of virology},
  year={2003},
  volume={77 24},
  pages={13407-11}
}
We examined CD8(+) T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8(+) T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8(+) T-cell response. 

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