Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma.

@article{Kohler2015DetailedAO,
  title={Detailed analysis of epithelial-mesenchymal transition and tumor budding identifies predictors of long-term survival in pancreatic ductal adenocarcinoma.},
  author={Ilona Kohler and Peter Bronsert and Sylvia Timme and Martin Werner and T. Brabletz and Ulrich Theodor Hopt and Oliver Schilling and Dirk Bausch and Tobias Keck and Ulrich F Wellner},
  journal={Journal of gastroenterology and hepatology},
  year={2015},
  volume={30 Suppl 1},
  pages={78-84}
}
BACKGROUND AND AIM Pancreatic ductal adenocarcinoma (PDAC) is characterized by aggressive biology and poor prognosis even after resection. Long-term survival is very rare and cannot be reliably predicted. Experimental data suggest an important role of epithelial-mesenchymal transition (EMT) in invasion and metastasis of PDAC. Tumor budding is regarded as the morphological correlate of local invasion and cancer cell dissemination. The aim of this study was to evaluate the biological and… CONTINUE READING