Detailed Molecular Model for Transfer Ribonucleic Acid

@article{Levitt1969DetailedMM,
  title={Detailed Molecular Model for Transfer Ribonucleic Acid},
  author={Michael Levitt},
  journal={Nature},
  year={1969},
  volume={224},
  pages={759-763}
}
  • M. Levitt
  • Published 1 November 1969
  • Chemistry, Medicine
  • Nature
A new model for transfer ribonucleic acid seems to explain the available experimental evidence better than do the models proposed hitherto. 
Proposed detailed structural model for tRNA and its geometric relationship to a messenger.
  • D. Abraham
  • Biology, Medicine
  • Journal of theoretical biology
  • 1971
TLDR
A new model for transfer ribonucleic acid is proposed which is different in concept from those published to date and a relationship of transfer RNA to messenger RNA is postulated to provide a molecular theory for protein biosynthesis. Expand
Estimation of Secondary Structure in Ribonucleic Acids
A simple method for estimating the secondary structure of an RNA molecule has been proposed on the basis of the knowledge of its sequence.
Structural studies on a tyrosine tRNA precursor.
Modification experiments strongly suggest that the clover leaf scheme for tRNA is the basic configuration adopted by tRNA precursors before maturation.
Structure Tridimensionnelle des Acides Ribonucléiques de Transfert
The aim of this review is to describe the present state of the problem of the three-dimensional structure of the tRNA’s.
Molecular Mechanics of Translation : a Reciprocating Ratchet Mechanism
A model is suggested for protein synthesis which depends upon conformational changes in tRNA and allosteric transitions in place of translocation.
Structure of yeast phenylalanine tRNA at 3 Å resolution
The structure of a tRNA has been determined by isomorphous replacement. Some of the interactions which maintain the tertiary structure are of a novel type. Our model differs significantly from oneExpand
Three-dimensional structure of yeast phenylalanine transfer RNA at 3. 0Å resolution
At 3Å resolution, the electron density map of crystalline tRNA shows the polynucleotide chain as an alternating series of ribose and phosphate peaks. Bases are seen, especially in the double helicalExpand
A model for the tertiary structure of tRNA.
  • C. Jang
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • 1973
Abstract A model for tRNA is described which has as its basic structural mode a four stranded RNA helix, formed by pairing two stems respectively from the four ubiquitous arms of the clover-leafExpand
Study of complexation of t-RNA by cis platinum
Abstract The results of an analysis of the structure and stability of different Pt-t-RNA complexes are presented.
Interaction between loops 1 and 3 in the tyrosine suppressor tRNA.
A mutant G to A base change in loop I of the tyrosine suppressor tRNA alters the reactivity towards methoxyamine of cytosines in loop III. This observation favours one of the previously describedExpand
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References

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Structure of a Ribonucleic Acid
The complete nucleotide sequence of an alanine transfer RNA, isolated from yeast, has been determined. This is the first nucleic acid for which the structure is known.
Crystallization of Transfer RNA
A bacterial transfer RNA (tRNAFMet) has been obtained in micro-crystalline form. Its probable unit cell dimensions have been deduced from X-ray powder photographs.
Nucleotide Sequence of a Yeast Tyrosine Transfer RNA
TLDR
The evidence indicates that the sequence containing guanosine, pseudouridine, and adenosine in the middle of the polynucleotide chain is the anticodon. Expand
Structure of Transfer RNA: Evidence for Interaction between Two Non-adjacent Nucleotide Residues in tRNAVal1 from Escherichia coli
These two letters describe the interaction between two non-adjacent residues in tRNAVal1 at position eight and thirteen, and a new model of the tRNA molecule that takes into account this restriction.
Crystallization of Transfer Ribonucleic Acids from Unfractionated Mixtures
A high yield of crystals of yeast tRNA has been obtained from unfractionated preparations. It appears that many of the tRNAs in the population possess such markedly similar conformational featuresExpand
Conformation of the Anticodon Loop in tRNA
A molecular model for the anticodon arm is proposed which is compatible with chemical, X-ray and genetic evidence. It provides a stereochemical basis for Crick's “wobble” hypothesis.
Nucleotide Sequence of N-Formyl-methionyl-transfer RNA
TLDR
The complete nucleotide sequence of this tRNA from Escherichia coli has been worked out and it is thought to be the chain-initiating tRNA of protein synthesis in bacterial systems. Expand
On the tertiary structure of transfer ribonucleic acid
TLDR
A model of the tertiary structure of t-RNA must take into account why selective chemical reactions specific for one base only show only limited reaction with the bases in the structured molecule. Expand
Studies on polynucleotides, lxviii the primary structure of yeast phenylalanine transfer RNA.
TLDR
The present report contains a brief account of the work leading to the elucidation of the nucleotide sequence of yeast phe-tRNA, characterized by the application of a technique developed for end-group labeling of 2',3'-diol residues in RNA. Expand
On the conformation of transfer RNA.
TLDR
The validity of this method has been proved in several investigations, and it can be used to determine the structure of tRNA, which is compatible with physicochemical, chemical, and biochemical evidence. Expand
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