Desynchronizing effect of levetiracetam on epileptiform responses in rat hippocampal slices.

@article{Niespodziany2003DesynchronizingEO,
  title={Desynchronizing effect of levetiracetam on epileptiform responses in rat hippocampal slices.},
  author={Isabelle Niespodziany and Henrik V Klitgaard and Doru Georg Margineanu},
  journal={Neuroreport},
  year={2003},
  volume={14 9},
  pages={1273-6}
}
The effect of levetiracetam on neuronal hypersynchrony and hyperexcitability was examined using simultaneous extra- and intracellular recordings in rat brain slices perfused with a high K+/low Ca2+ (HKLC) fluid. These findings were compared to results obtained with carbamazepine, valproate and clonazepam. The HKLC milieu induces in hippocampal CA3 area, spontaneous interictal bursts and epileptiform responses. Levetiracetam decreased the number of population spikes per extracellular response… CONTINUE READING