Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor

@article{Deecher2006DesvenlafaxineSA,
  title={Desvenlafaxine Succinate: A New Serotonin and Norepinephrine Reuptake Inhibitor},
  author={Darlene C. Deecher and Chad E. Beyer and Grace H. Johnston and Jenifer A. Bray and S. Shah and Magid A Abou-Gharbia and Terrance H. Andree},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2006},
  volume={318},
  pages={657 - 665}
}
  • D. Deecher, C. Beyer, T. Andree
  • Published 1 August 2006
  • Biology, Chemistry, Medicine
  • Journal of Pharmacology and Experimental Therapeutics
The purpose of this study was to characterize a new chemical entity, desvenlafaxine succinate (DVS). DVS is a novel salt form of the isolated major active metabolite of venlafaxine. Competitive radioligand binding assays were performed using cells expressing either the human serotonin (5-HT) transporter (hSERT) or norepinephrine (NE) transporter (hNET) with Ki values for DVS of 40.2 ± 1.6 and 558.4 ± 121.6 nM, respectively. DVS showed weak binding affinity (62% inhibition at 100 μM) at the… 

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