Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin.

@article{Kadoya2002DesumoylationAO,
  title={Desumoylation activity of Axam, a novel Axin-binding protein, is involved in downregulation of beta-catenin.},
  author={Takayuki Kadoya and Hideki Yamamoto and Toshiaki Suzuki and Akira Yukita and Akimasa Fukui and Tatsuo Michiue and Toshimasa Asahara and Keiji Tanaka and Makoto Asashima and Akira Kikuchi},
  journal={Molecular and cellular biology},
  year={2002},
  volume={22 11},
  pages={3803-19}
}
Axam has been identified as a novel Axin-binding protein that inhibits the Wnt signaling pathway. We studied the molecular mechanism by which Axam stimulates the downregulation of beta-catenin. The C-terminal region of Axam has an amino acid sequence similar to that of the catalytic region of SENP1, a SUMO-specific protease (desumoylation enzyme). Indeed, Axam exhibited activity to remove SUMO from sumoylated proteins in vitro and in intact cells. The Axin-binding domain is located in the… CONTINUE READING