Desulfation of cell surface HSPG is an effective strategy for the treatment of gallbladder carcinoma.

@article{Yi2016DesulfationOC,
  title={Desulfation of cell surface HSPG is an effective strategy for the treatment of gallbladder carcinoma.},
  author={B. Yi and Y. Qiu and Weidan Ji and Miaoyan Wei and Chunying Liu and Zhangxiao Peng and Yongjie Zhang and Z. Quan and Zhao-hui Tang and C. Su},
  journal={Cancer letters},
  year={2016},
  volume={381 2},
  pages={
          349-58
        }
}
Cell surface heparan sulfate proteoglycan (HSPG) is a group of critical glycoproteins that mediates signal transduction. Sulfated HSPG can mediate the activation of a variety of cell growth factor signal pathway to promote the progression of gallbladder carcinoma (GBC). This study analyzed 527 clinical GBC specimens and confirmed that the HSPG sulfation level was significantly higher in GBC tissues than in gallbladder mucosa (GBM) tissues. The high HSPG sulfation level was closely associated… Expand

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