Destroying worn-out cells makes mice live longer

@article{Callaway2016DestroyingWC,
  title={Destroying worn-out cells makes mice live longer},
  author={Ewen Callaway},
  journal={Nature},
  year={2016}
}
Elegant experiment confirms that targeting senescent cells could treat age-related diseases. 

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It is shown that compared to vehicle alone, AP20187 treatment extended median lifespan in both male and female mice of two distinct genetic backgrounds and the clearance of p16Ink4a-positive cells delayed tumorigenesis and attenuated age-related deterioration of several organs without apparent side effects. Expand
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
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Data indicate that cellular senescence is causally implicated in generating age-related phenotypes and that removal of senescent cells can prevent or delay tissue dysfunction and extend healthspan. Expand