Destabilization of fructose 1,6-bisphosphatase-Z-line interactions is a mechanism of glyconeogenesis down-regulation in vivo.

@article{Gizak2013DestabilizationOF,
  title={Destabilization of fructose 1,6-bisphosphatase-Z-line interactions is a mechanism of glyconeogenesis down-regulation in vivo.},
  author={Agnieszka Gizak and Jakub Mazurek and Marta Wozniak and Ewa Maciaszczyk-Dziubińska and Dariusz Rakus},
  journal={Biochimica et biophysica acta},
  year={2013},
  volume={1833 3},
  pages={622-8}
}
Although it is well known that insulin controls the synthesis of glycogen from non-carbohydrates by down-regulating expression of several glyconeogenic enzymes, a mechanism of short-term inhibition of glyconeogenesis remains unknown. In recent years, we have shown that in skeletal muscle, fructose 1,6-bisphosphatase (FBPase) is a part of the hypothetical glyconeogenic complex located on sarcomeric Z-line. Here, we show that inhibition of glycogen synthase kinase-3 causes disruption of the… CONTINUE READING