Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway.

@article{Schulte1996DestabilizationOR,
  title={Destabilization of Raf-1 by geldanamycin leads to disruption of the Raf-1-MEK-mitogen-activated protein kinase signalling pathway.},
  author={Theodor W. Schulte and Mikhail V. Blagosklonny and Liudmila Romanova and J. Frederic Mushinski and Brett P. Monia and Joseph F. Johnston and Phoungmai Nguyen and Jane B. Trepel and Leonard M. Neckers},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 10},
  pages={5839-45}
}
The serine/threonine kinase Raf-1 functions downstream of Rats in a signal transduction cascade which transmits mitogenic stimuli from the plasma membrane to the nucleus. Raf-1 integrates signals coming from extracellular factors and, in turn, activates its substrate, MEK kinase. MEK activates mitogen-activated protein kinase (MAPK), which phosphorylates… CONTINUE READING