Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson's disease.

@article{Hulleman2007DestabilizationOD,
  title={Destabilization of DJ-1 by familial substitution and oxidative modifications: implications for Parkinson's disease.},
  author={John D. Hulleman and Hamid Mirzaei and Emmanuel Guigard and Kellie L Taylor and Soumya S. Ray and Cyril M. Kay and Fred E. Regnier and Jean-Christophe Rochet},
  journal={Biochemistry},
  year={2007},
  volume={46 19},
  pages={5776-89}
}
Parkinson's disease (PD) is a neurodegenerative disorder characterized by oxidative stress and protein aggregation. Both toxic phenomena are mitigated by DJ-1, a homodimeric protein with proposed antioxidant and chaperone activities. The neuroprotective function of DJ-1 is modulated by oxidation of cysteine 106, a residue that may act as an oxidative stress sensor. Loss-of-function mutations in the DJ-1 gene have been linked to early onset PD, and age-dependent over-oxidation of DJ-1 is thought… CONTINUE READING

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