Destabilization of Alzheimer's Aβ42 Protofibrils with a Novel Drug Candidate wgx-50 by Molecular Dynamics Simulations.

@article{Fan2015DestabilizationOA,
  title={Destabilization of Alzheimer's Aβ42 Protofibrils with a Novel Drug Candidate wgx-50 by Molecular Dynamics Simulations.},
  author={Huai-Meng Fan and Ruo-Xu Gu and Yan-jing Wang and Yun-Long Pi and Yonghong Zhang and Qin Xu and Dongqing Wei},
  journal={The journal of physical chemistry. B},
  year={2015},
  volume={119 34},
  pages={11196-202}
}
Alzheimer's disease (AD) is one of the most common dementia. The aggregation and deposition of the amyloid-β peptide (Aβ) in neural tissue is its characteristic symptom. To destabilize and dissolve Aβ fibrils, a number of candidate molecules have been proposed. wgx-50 is a compound extracted from Sichuan pepper (Zanthoxylum bungeanum) and a potential candidate drug for treating AD. Our early experiments show it is effective in disassembling Aβ42 aggregations. A series of molecular dynamics… CONTINUE READING