Destabilization and early termination of spiral-wave reentry by a class III antiarrhythmic agent, nifekalant, in a perfused two-dimensional layer of rabbit ventricular myocardium.

Abstract

Nifekalant (NF) is a novel class III antiarrhythmic agent that is effective in preventing recurrent life-threatening ventricular tachycardia/fibrillation (VT/VF). However, because the mechanism underlying the antiarrhythmic action of NF is unknown, we investigated the effects of NF on the dynamics of functional reentry in rabbit hearts. A 2D subepicardial… (More)

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Cite this paper

@article{Yamazaki2006DestabilizationAE, title={Destabilization and early termination of spiral-wave reentry by a class III antiarrhythmic agent, nifekalant, in a perfused two-dimensional layer of rabbit ventricular myocardium.}, author={Masatoshi Yamazaki and Haruo Honjo and Harumichi Nakagawa and Yuko S. Ishiguro and Yusuke Okuno and Mari Amino and Ichiro Sakuma and Kaichiro Kamiya and Itsuo Kodama}, journal={Circulation research}, year={2006}, volume={98 3}, pages={e28} }