Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion

@article{Myrnp2006DesquamationOH,
  title={Desquamation of human coronary artery endothelium by human mast cell proteases: implications for plaque erosion},
  author={Mikko I. M{\"a}yr{\"a}np{\"a}{\"a} and Hanna M Heikkil{\"a} and Ken A. Lindstedt and A F Walls and Petri T. Kovanen},
  journal={Coronary Artery Disease},
  year={2006},
  volume={17},
  pages={611-621}
}
ObjectiveEndothelial erosion has emerged as an important contributor to the pathogenesis of atherosclerosis and its complications, but the molecular mechanisms have remained unclear. As activated mast cells capable of secreting neutral proteases are present in the intima of eroded coronary plaques, we investigated their potential roles in endothelial erosion. Methods and resultsStudies involving double immunostaining of mast cells (tryptasepos cells) and platelets (CD42b) in human coronary… 
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