Despite Blocking Doxorubicin-Induced Vascular Damage, Quercetin Ameliorates Its Antibreast Cancer Activity

@article{Henidi2020DespiteBD,
  title={Despite Blocking Doxorubicin-Induced Vascular Damage, Quercetin Ameliorates Its Antibreast Cancer Activity},
  author={Hanan Ali Henidi and Fahad A. Al-Abbasi and Mohamed Ahmed El-Moselhy and Hany M El-Bassossy and Ahmed M. Al-Abd},
  journal={Oxidative Medicine and Cellular Longevity},
  year={2020},
  volume={2020}
}
Quercetin is a naturally occurring flavonol present in many foods. Doxorubicin is an effective anticancer agent despite its dose-limiting cardiovascular toxicity. Herein, we investigated the potential protective effects of quercetin against doxorubicin-induced vascular toxicity and its effect on the therapeutic cytotoxic profile of doxorubicin in breast cancer cell lines. The incubation of isolated aortic rings with doxorubicin produced concentration-dependent exaggeration of vasoconstriction… 

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