Desperately seeking microRNA targets

  title={Desperately seeking microRNA targets},
  author={Marshall Thomas and Judy Lieberman and Ashish Nandan Lal},
  journal={Nature Structural &Molecular Biology},
MicroRNAs (miRNAs) suppress gene expression by inhibiting translation, promoting mRNA decay or both. Each miRNA may regulate hundreds of genes to control the cell's response to developmental and other environmental cues. The best way to understand the function of a miRNA is to identify the genes that it regulates. Target gene identification is challenging because miRNAs bind to their target mRNAs by partial complementarity over a short sequence, suppression of an individual target gene is often… CONTINUE READING